Benefits and Process Improvements

• Increase Productivity
  • increase yield
  • reduce cycle time
  • eliminate/consolidate unit operations
  • increase reactor volume efficiency

• Improve Environmental Performance

  • eliminate, reduce or replace solvent
  • reduce excess volatile or hazardous reactants

• Increase Quality

  • improve selectivity
  • reduce variability

• Enhance Safety

  • control exotherms
  • use less hazardous alternate raw materials
  • reduce excess hazardous reactants

• Reduce Other Manufacturing Costs

  • replace NaOMe/OEt, t-butoxide, NaH, NaNH_2, Na metal with inexpensive inorganic base!!!
  • replace DMSO, NMP, DMF, DMA, chlorinated hydrocarbon solvents
  • are you using use water-sensitive reactants acyl Cl, mesyl Cl, PCl₃, POCl₃, others?
  • would you like to use alternate less expensive or easier to handle raw materials?